Safe, Effective & Non-Hormonal: How Does Saheli Plus Prevent Pregnancy?

By Saheli Plus | July 4, 2025

Contraception is one of the modern innovations that have shaped human society. It has been not just a tool for population control and keeping the numbers in check, but also a powerful tool for family planning, implementing child spacing and ensuring women's reproductive health. It has also brought numerous indirect benefits: contraception has been an empowering tool that supports women's education, career, financial planning, autonomy, financial independence, and gender equality.

But the choice of contraception method has massive implications in terms of health and long-term wellness. For instance, condoms are the most widely available contraception method; they are effective, easy to use, and affordable. However, they require men's participation, and barrier methods come at the cost of pleasure. Therefore, the adoption rate of condoms is relatively low compared to permanent sterilisation methods for women, which are painful, invasive, and involve surgical procedures. It is evident from the NFHS-5 data: less than one in ten men (9.5%) used condoms, whereas female sterilisation was used by 37.9% of women.

Other options like hormonal OCPs come with a lot of side effects and affect natural hormonal balance. So, the need for contraceptive innovations that bring safety, affordability, convenience, and ease of use is high.

In this context, Saheli Plus, India's own non-hormonal oral contraceptive, stands out as a revolutionary alternative for women seeking safe, effective, and side-effect-free contraception. This article explores how Saheli Plus works and how it achieves safe and effective contraception without upsetting the hormonal balance.

What is Saheli Plus?

Saheli Plus is an Oral Contraceptive Pill (OCP) that stands out from the rest in terms of composition, how it achieves contraception, dosage, and the lack of side effects. Unlike any other OCP available in the market, Saheli Plus does not contain synthetic hormones and is free from any side effects. It is a safe, non-hormonal contraceptive with a weekly dosage schedule and is made of the active molecule, Centchroman.

  • World's first non-hormonal oral contraceptive pill (OCP)
  • No hormones, no side effects
  • Follows a unique weekly dosage schedule
  • Affordable and accessible
  • Based on the revolutionary Centchroman compound developed by CDRI, Lucknow
  • Backed by extensive research for more than four decades
  • Does not disrupt natural hormonal balance
  • Safe for long-term use
  • Easily reversible

Saheli's Impact and Proven Effectiveness

Saheli's effectiveness and lack of side effects were proven not only by research under controlled conditions, but also in the real world. It was approved for use in the National Family Planning Programme and is now available free of cost at Primary Healthcare Centres. It is trusted by lakhs of Indian women for its convenience, safety, and non-interference with hormonal balance.

How Does Saheli Plus Compare With The Conventional Hormonal Pills?

Hormonal OCPsSaheli Plus
Active ingredientOestrogen + Progestin / Progestin onlyCentchroman (Selective Estrogen Receptor Modulator)
DosageDailyTwice a week for the first 3 months, once a week thereafter
How it achieves contraceptionHormonal suppression of ovulationModulation of oestrogen receptors
Hormonal side effectsCommon (weight gain, nausea, mood swings)None
Menstrual impactCan cause irregular bleeding or spottingStabilises naturally after adjustment
Reversing contraceptionMay take weeks to monthsRapid return after stopping
Impact on gut healthCan disrupt microbiotaNone
CostModerate to highLow with weekly dosage
AccessibilityPharmaciesPharmacies + Govt health centres

So, How Does Saheli Plus Work?

1. Oestrogen Receptor Modulation

Saheli Plus binds selectively to oestrogen receptors in reproductive tissues. This blocks oestrogen activity in the uterus without affecting the menstrual cycle or ovulation.

2. Delayed Endometrial Maturation

By blocking oestrogen in the uterus, Saheli Plus delays the development of the uterine lining, making it unsuitable for implantation of a fertilised egg.

3. Accelerated Transport of the Fertilised Egg

Saheli Plus speeds up the transport of the fertilised egg, which then arrives in the uterus prematurely, before the lining is ready—creating dual-layered contraceptive protection.

4. The Dual Nature of Saheli Plus

As a SERM, it is anti-oestrogenic in the uterus and oestrogenic in organs like bones and the cardiovascular system, where oestrogen has a protective function.

How Saheli Plus' Non-Hormonal Nature Preserves Hormonal Balance and Reproductive Health

  • Free from side effects typically caused by hormonal pills (e.g., weight gain, nausea)
  • Maintains gut microbiome health, important for fertility
  • Allows a quick return to fertility after discontinuation
  • Does not worsen conditions like PCOS or endometriosis
  • Suitable for breastfeeding women
  • Supports both reproductive and menstrual health naturally

Saheli Plus: A Safer Way Forward in Contraception

Saheli Plus, based on Centchroman, has helped millions of Indian women take control of their fertility. It offers reliable contraception, no side effects, and full reversibility. Whether it's for birth spacing or long-term planning, it provides a non-invasive, affordable, and empowering alternative to traditional methods.

FAQs

1. What is Saheli Plus, and how does it work?
Saheli Plus is a non-hormonal weekly oral contraceptive pill. It works by modulating oestrogen receptors to prevent implantation, without suppressing ovulation.

2. Does Saheli Plus have any side effects?
No. It is free from side effects and has been proven safe in long-term studies.

3. Is Saheli Plus suitable for long-term use?
Yes. It is reversible and suitable for extended use without health risks.

4. Can Saheli Plus be used for endometriosis?
Yes. Its non-hormonal mechanism makes it safe for women managing endometriosis or hormonal imbalance.

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